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1

The chemistry of metal–organic frameworks for CO2 capture, regeneration and conversion

Trickett, Christopher A., Helal, Aasif, Al-Maythalony, Bassem A., Yamani, Zain H., Cordova, Kyle E., Yaghi, Omar M.

Journal:

Nature Reviews Materials

Year:

2017

Language:

english

File:

PDF, 8.96 MB

english, 2017

2

Synthetic Approaches to the New Drugs Approved During 2017

Flick, Andrew C, Leverett, Carolyn A, Ding, Hong Xia, McInturff, Emma L, Fink, Sarah J., Helal, Christopher J., O'Donnell, Christopher J.

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 831 KB

english, 2019

3

A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow

Perera, Damith, Tucker, Joseph W., Brahmbhatt, Shalini, Helal, Christopher J., Chong, Ashley, Farrell, William, Richardson, Paul, Sach, Neal W.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.51 MB

english, 2018

4

Synthetic Approaches to the New Drugs Approved During 2018

Flick, Andrew, Leverett, Carolyn A, Ding, Hong Xia, McInturff, Emma L, Fink, Sarah, Helal, Christopher, Deforest, Jacob, Morse, Peter, Mahapatra, Subham, O'Donnell, Christopher J.

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.06 MB

2020

5

Stereoselective Synthesis of cis-1,3-Disubstituted Cyclobutyl Kinase Inhibitors.

Christopher J. Helal, Zhijun Kang, John C. Lucas, Brooks R. Bohall

Journal:

Year:

2004

File:

PDF, 21 KB

2004

6

Novel electronic effects of remote substituents on the oxazaborolidine-catalyzed enantioselective reduction of ketones

E.J. Corey, Christopher J. Helal

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 354 KB

english, 1995

7

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease

Christopher J. Helal, Zhijun Kang, John C. Lucas, Thomas Gant, Michael K. Ahlijanian, Joel B. Schachter, Karl E.G. Richter, James M. Cook, Frank S. Menniti, Kristin Kelly, Scot Mente, Jay Pandit, Nata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.18 MB

english, 2009

8

A catalytic enantioselective synthesis of chiral monosubstituted oxiranes

E.J. Corey, Christopher J. Helal

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 276 KB

english, 1993

9

Design and Discovery of 6-[(3 S ,4 S )-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2 H -pyran-4-yl)-1,5-dihydro-4 H -pyrazolo[3,4- d ]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders

Verhoest, Patrick R., Fonseca, Kari R., Hou, Xinjun, Proulx-LaFrance, Caroline, Corman, Michael, Helal, Christopher J., Claffey, Michelle M., Tuttle, Jamison B., Coffman, Karen J., Liu, Shenpinq, Nels

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 4.59 MB

english, 2012

10

Stereoselective Synthesis of cis -1,3-Disubstituted Cyclobutyl Kinase Inhibitors

Helal, Christopher J., Kang, Zhijun, Lucas, John C., Bohall, Brooks R.

Journal:

Organic Letters

Year:

2004

Language:

english

File:

PDF, 77 KB

english, 2004

11

β-secretase inhibitors for treatment of Alzheimer's disease

O'Neill, Brian T., Brodney, Michael A., Ambroise, Claude, Borzilleri, Kris, Coffman, Karen, Efremov, Ivan, Hajos-Korcsok, Eva, Helal, Christopher, Kauffman, Gregory, Lanyon, Lorraine, Liston, Dane, Ji

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 46 KB

english, 2010

12

A self-adjuvanted nanoparticle based vaccine against infectious bronchitis virus

Li, Jianping, Helal, Zeinab H., Karch, Christopher P., Mishra, Neha, Girshick, Theodore, Garmendia, Antonio, Burkhard, Peter, Khan, Mazhar I., Ho, Paulo Lee

Journal:

Year:

2018

Language:

english

File:

PDF, 9.17 MB

english, 2018

13

Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization

Davoren, Jennifer E., Nason, Deane M, Coe, Jotham, Dlugolenski, Keith, Helal, Christopher J., Harris, Anthony R., LaChapelle, Erik, Liang, Sidney, Liu, Yue, O'Connor, Rebecca E, Orozco, Christine C, R

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 575 KB

english, 2018

14

Ectopic Spinal Calcification Associated with Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Quantitative Micro-CT Analysis

Fournier, Dale E., Norley, Chris J. D., Pollmann, Steven I., Bailey, Christopher S., Helal, Fahad Al, Willmore, Katherine E., Holdsworth, David W., Dixon, Jeffrey, Séguin, Cheryle A.

Journal:

Journal of Orthopaedic Research

Year:

2019

Language:

english

File:

PDF, 1.15 MB

english, 2019

15

Quick Building Blocks (QBB): An Innovative and Efficient Business Model to Speed Medicinal Chemistry Analog Synthesis

Helal, Christopher J., Bundesmann, Mark W, Hammond, Susan J, Holmstrom, Melissa, Klug-McLeod, Jacquelyn L, Lefker, Bruce A, McLeod, Dale G, Subramanyam, Chakrapani, Zakaryants, Oleg, Sakata, Sylvie

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 408 KB

english, 2019

16

Catalytic Enantioselective Synthesis of a cis -Î²-Boronyl Cyclobutylcarboxyester Scaffold and Its Highly Diastereoselective Nickel/Photoredox Dual-Catalyzed Csp 3 âCsp 2 Cross-Coupling to Access Elusive trans -Î²-Aryl/Heteroaryl Cyclobutylcarboxyesters

Nguyen, Kevin, Clement, Helen A., Bernier, Louise, Coe, Jotham W., Farrell, William, Helal, Christopher J., Reese, Matthew R., Sach, Neal W., Lee, Jack C., Hall, Dennis G.

Journal:

Year:

2021

File:

PDF, 2.72 MB

2021

17

Reduktion von Carbonylverbindungen mit chiralen Oxazaborolidin-Katalysatoren: eine neue enantioselektive Katalyse und leistungsfähige Synthesemethode

Elias J. Corey, Christopher J. Helal

Journal:

Angewandte Chemie

Year:

1998

Language:

german

File:

PDF, 559 KB

german, 1998

18

Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method

Elias J. Corey, Christopher J. Helal

Journal:

Angewandte Chemie International Edition

Year:

1998

Language:

english

File:

PDF, 527 KB

english, 1998

19

A Concise and Regioselective Synthesis of 1-Alkyl-4-imidazolecarboxylates.

Christopher J. Helal, John C. Lucas

Journal:

Year:

2003

File:

PDF, 94 KB

2003

20

Discovery and SAR of 2-Aminothiazole Inhibitors of Cyclin-Dependent Kinase 5/p25 as a Potential Treatment for Alzheimer′s Disease.

Christopher J. Helal, et al. et al.

Journal:

Year:

2005

File:

PDF, 12 KB

2005

21

Catalytic enantioselective synthesis of the second generation histamine antagonist cetirizine hydrochloride

E.J. Corey, Christopher J. Helal

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 208 KB

english, 1996

22

Asymmetric synthesis of (S)-carbinoxamine. New aspects of oxazaborolidine-catalyzed enantioselective carbonyl reduction

E.J Corey, Christopher J Helal

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 257 KB

english, 1996

23

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease

Christopher J. Helal, Mark A. Sanner, Christopher B. Cooper, Thomas Gant, Mavis Adam, John C. Lucas, Zhijun Kang, Stanley Kupchinsky, Michael K. Ahlijanian, Bonnie Tate, Frank S. Menniti, Kristin Kell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 289 KB

english, 2004

24

A facile synthesis of 2,3-azaisoindoline

Subas M. Sakya, Michel Van Den Berg, Kees Pouwer, John M. Humphrey, Christopher J. Helal, Christopher J. O’Donnell

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 358 KB

english, 2010

25

An Efficient Catalytic Stereoselective Route to a Key Intermediate for the Synthesis of the Long-Lived PGI2 Analog ZK 96480 (CicaprostTM)

E.J Corey, Christopher J Helal

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 491 KB

english, 1997

26

Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition

Chappie, Thomas A., Helal, Christopher J., Hou, Xinjun

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 7.21 MB

english, 2012

27

A Concise and Regioselective Synthesis of 1-Alkyl-4-imidazolecarboxylates

Helal, Christopher J., Lucas, John C.

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 34 KB

english, 2002

28

Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors

Claffey, Michelle M., Helal, Christopher J., Verhoest, Patrick R., Kang, Zhijun, Fors, Kristina S., Jung, Stanley, Zhong, Jiaying, Bundesmann, Mark W., Hou, Xinjun, Lui, Shenping, Kleiman, Robin J., V

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

29

Stereoselective Synthesis of Spiropiperidines as BACE-1 Aspartyl Protease Inhibitors via Late Stage N -Arylation of a 1,8-Diazaspiro[4.5]dec-3-en-2-one Pharmacophore

Lee, Che-Wah, Lira, Ricardo, Dutra, Jason, Ogilvie, Kevin, O’Neill, Brian T., Brodney, Michael, Helal, Christopher, Young, Joseph, Lachapelle, Erik, Sakya, Subas, Murray, John C.

Journal:

Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 707 KB

english, 2013

30

Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

Zhang, Lei, Villalobos, Anabella, Beck, Elizabeth M., Bocan, Thomas, Chappie, Thomas A., Chen, Laigao, Grimwood, Sarah, Heck, Steven D., Helal, Christopher J., Hou, Xinjun, Humphrey, John M., Lu, Jiem

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 572 KB

english, 2013

31

Continent Colonic Urinary Reservoir (Florida Pouch): Long-Term Surgical Complications (Greater Than 11 Years)

WEBSTER, CHRISTOPHER, BUKKAPATNAM, RAVIENDER, SEIGNE, JOHN D., POW-SANG, JULIO, HOFFMAN, MITCHELL, HELAL, MOHAMED, ORDORICA, RAUL, LOCKHART, JORGE L.

Journal:

The Journal of Urology

Year:

2003

Language:

english

File:

PDF, 59 KB

english, 2003

32

Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

Verhoest, Patrick R., Proulx-Lafrance, Caroline, Corman, Michael, Chenard, Lois, Helal, Christopher J., Hou, Xinjun, Kleiman, Robin, Liu, Shenping, Marr, Eric, Menniti, Frank S., Schmidt, Christopher

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 3.28 MB

english, 2009

33

Direct Catalytic Enantioselective Reduction of Achiral α,β-Ynones. Strong Remote Steric Effects Across the C−C Triple Bond

Helal, Christopher J., Magriotis, Plato A., Corey, E. J.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 134 KB

english, 1996

34

Stereoselective Synthesis of 1,3-Disubstituted Cyclobutyl Kinase Inhibitors

Helal, Christopher J., Kang, Zhijun, Lucas, John C., Bohall, Brooks R.

Journal:

Organic Letters

Year:

2004

Language:

english

File:

PDF, 7 KB

english, 2004

35

Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia

Helal, Christopher J., Kang, Zhijun, Hou, Xinjun, Pandit, Jayvardhan, Chappie, Thomas A., Humphrey, John M., Marr, Eric S., Fennell, Kimberly F., Chenard, Lois K., Fox, Carol, Schmidt, Christopher J.,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.96 MB

english, 2011

36

[IEEE 2006 13th IEEE International Conference on Electronics, Circuits and Systems - Nice, France (2006.12.10-2006.12.13)] 2006 13th IEEE International Conference on Electronics, Circuits and Systems - Digital Radio Front-End for High Data Rate Impulse UWB System

Morche, Dominique, Hameau, Frederic, Lachartre, David, Masson, Gilles, Mounet, Christopher, Pelissier, Michael, Helal, Didier, Smaini, Lydi, Belot, Didier

Year:

2006

Language:

english

File:

PDF, 1.05 MB

english, 2006

37

Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design

Butler, Christopher R., Brodney, Michael A., Beck, Elizabeth M., Barreiro, Gabriela, Nolan, Charles E., Pan, Feng, Vajdos, Felix, Parris, Kevin, Varghese, Alison H., Helal, Christopher J., Lira, Ricar

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 3.06 MB

english, 2015

38

Discovery of the potent and selective M1 PAM-agonist N-[(3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of efficacy and cholinergic side effects

Davoren, Jennifer Elizabeth, Lee, Che-Wah, Garnsey, Michelle, Brodney, Michael A., Cordes, Jason, Dlugolenski, Keith, Edgerton, Jeremy R., Harris, Antony R., Helal, Christopher J., Jenkinson, Stephen,

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.75 MB

english, 2016

39

Vaccination with self-adjuvanted protein nanoparticles provides protection against lethal influenza challenge

Karch, Christopher P., Li, Jianping, Kulangara, Caroline, Paulillo, Sara M., Raman, Senthil K., Emadi, Sharareh, Tan, Anmin, Helal, Zeinab H., Fan, Qing, Khan, Mazhar I., Burkhard, Peter

Journal:

Nanomedicine: Nanotechnology, Biology and Medicine

Year:

2016

Language:

english

File:

PDF, 1.61 MB

english, 2016

40

Numerical and experimental studies on a Building integrated Semi-transparent Photovoltaic Thermal (BiSPVT) system: Model validation with a prototype test setup

Gaur, Ankita, Tiwari, G.N., Ménézo, Christophe, Al-Helal, I.M.

Journal:

Energy Conversion and Management

Year:

2016

Language:

english

File:

PDF, 1.76 MB

english, 2016

41

Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy

Pettersson, Martin, Johnson, Douglas S., Rankic, Danica A., Kauffman, Gregory W., am Ende, Christopher W., Butler, Todd W., Boscoe, Brian, Evrard, Edelweiss, Helal, Christopher J., Humphrey, John M.,

Journal:

Year:

2017

Language:

english

File:

PDF, 1.41 MB

english, 2017

42

Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Helal, Christopher J., Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A., Fennell, Kimberly F., Forman, Michael D, Hajós, Mihaly, Harms, John F., Hoffmann, William E., Humphrey, John

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.51 MB

english, 2017

43

Ru/Ni Dual Catalytic Desulfinative Photoredox C sp 2 –C sp 3 Cross-Coupling of Alkyl Sulfinate Salts and Aryl Halides

Knauber, Thomas, Chandrasekaran, Ramalakshmi, Tucker, Joseph W., Chen, Jinshan Michael, Reese, Matthew, Rankic, Danica A., Sach, Neal, Helal, Christopher

Journal:

Organic Letters

Year:

2017

Language:

english

File:

PDF, 840 KB

english, 2017

44

Parallel Synthesis of 1 H- Pyrazolo[3,4- d ]pyrimidines via Condensation of N -Pyrazolylamides and Nitriles

Shah, Akshay A., Chenard, Lois K., Tucker, Joseph W., Helal, Christopher J.

Journal:

ACS Combinatorial Science

Year:

2017

Language:

english

File:

PDF, 1.35 MB

english, 2017

45

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate

Helal, Christopher J., Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A., Fisher, Ethan, Hajós, Mihaly, Harms, John F., Hoffmann, William E., Humphrey, John M., Pandit, Jayvardhan, Ka

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 967 KB

english, 2018

46

Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189

Stepan, Antonia F., Tran, Tuan P., Helal, Christopher J., Brown, Maria S, Chang, Cheng, O'Connor, Rebecca E, De Vivo, Michael, Doran, Shawn D, Fisher, Ethan L., Jenkinson, Stephen, Karanian, David, Ko

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 1.08 MB

english, 2018

47

Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides

Zhou, Hua, Mukherjee, Paramita, Liu, Rongqiang, Evrard, Edelweiss, Wang, Dianpeng, Humphrey, John M., Butler, Todd W., Hoth, Lise R., Sperry, Jeffrey B., Sakata, Sylvie K., Helal, Christopher J., am E

Journal:

Organic Letters

Year:

2018

Language:

english

File:

PDF, 1.26 MB

english, 2018

48

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation

McAllister, Laura A., Butler, Christopher R., Mente, Scot, O'Neil, Steven V., Fonseca, Kari R., Piro, Justin R., Cianfrogna, Julie A., Foley, Timothy L., Gilbert, Adam M., Harris, Anthony R., Helal, C

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.32 MB

english, 2018

49

Increased building block access through collaboration

Helal, Christopher J., Bartolozzi, Alessandra, Goble, Steven D., Mani, Neelakanda S., Guzman-Perez, Angel, Ohri, Ajay K., Shi, Zhi-Cai, Subramanyam, Chakrapani

Journal:

Drug Discovery Today

Year:

2018

Language:

english

File:

PDF, 523 KB

english, 2018

50

Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Helal, Christopher J., Arnold, Eric P., Boyden, Tracey L., Chang, Cheng, Chappie, Thomas A., Fennell, Kimberly F., Forman, Michael D., Hajos, Mihaly, Harms, John F., Hoffman, William E., Humphrey, Joh

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 187 KB

english, 2018

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